Trial of high dosages of dapsone in the treatment of tuberculoid leprosy.

Two groups, each of 1 00 patients suffering from tuberculoid leprosy, were treated with different dosages of dapsone, the control group being given a conservative dosage of the drug and the study group a high dosage ( 1 200 mg weekly) . The patients in the high-dosage group showed more rapid regression of the disease , a lower incidence of relapse and early regression of the tingling, enlargement and tenderness of the nerve involved. Dapsone in a dosage of 1 200 mg weekly was well tolerated by these patients with active tuberculoid leprosy.